Ivermectin impairs memory retrieval performance by B6 Nestin-cre mice

This dataset includes measurements collected from behavioural experiments investigating the role of
adult-born neurons in the hippocampal dentate gyrus and its significance in memory processes. We
investigated the feasibility of ivermectin-based chemogenetic manipulation of recently born neurons
in the hippocampus in altering spatial and contextual memory retrieval. The adult-born neurons were
targeted using a nestin-cre mouse model, employing lentivirus-mediated transduction of inhibitory
chloride channel constructs sensitive or insensitive to ivermectin in order to be able to silence
them during different developmental stages. The dataset includes results from two mouse age groups:
5 weeks and 5 months old at the time of lentivirus injection. Additionally, data were recorded from
mice undergoing the same tests without any lentivirus-mediated channel overexpression. Data include
recordings from Morris water maze and contextual fear conditioning experiments for the treatment groups.
Treatment groups included i) active channel expressing treated with vehicle solution, ii) active channel
expressing treated with ivermectin solution, and iii) inactive channel expressing treated with ivermectin
solution. For mice that were not injected with lentivirus, two groups are compared: one treated with
vehicle and one with ivermectin.