Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-isopropylbenzyl)thiazole-4-carboxylic acid

Crystal structure of B3 L1 MBL in complex with 2-amino-5-(4-isopropylbenzyl)thiazole-4-carboxylic acid Descriptor: 2-azanyl-5-[(4-propan-2-ylphenyl)methyl]-1,3-thiazole-4-carboxylic acid, GLYCEROL, Metallo-beta-lactamase L1 type 3, ... Authors: Yan, Y.-H, Zhu, K.-R, Li, G.-B. Deposit date: 2023-01-04 Release date: 2023-11-01 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. J.Med.Chem., 66, 2023与2-氨基-5-(4-异丙基苄基)噻唑-4-羧酸结合的B3 L1型金属β-内酰胺酶（Metallo-beta-lactamase, MBL）的晶体结构 配体描述：2-氨基-5-[(4-异丙基苯基)甲基]-1,3-噻唑-4-羧酸、甘油（GLYCEROL）、L1型3金属β-内酰胺酶等 作者：Yan Y.-H、Zhu K.-R、Li G.-B 提交日期：2023-01-04 发布日期：2023-11-01 最后修改日期：2024-10-23 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.81埃（Å） 引用文献：《通过模拟碳青霉烯水解产物结合模式发现2-氨基噻唑-4-羧酸类广谱金属β-内酰胺酶抑制剂》，J.Med.Chem., 66, 2023