MICs of BDQ and CFZ of clinical isolates, in the absence and presence of reserpine.

MICs and mutations in Rv0678 gene are shown for baseline and post-baseline isolates of each patient. For MICs without reserpine, fold-changes between brackets represent the difference between resistant and wild-type MICs. For MICs in the presence of reserpine (3 µg/ml), fold-changes between brackets represent the differences between MIC with and without reserpine. wt: wild-type; Ins: insertion; Del: deletion; nt: nucleotide; BDQ: bedaquiline; CFZ: clofazimine; RES: reserpine.