The active form of Mef2c promotes maturation of induced cardiomyocytes
收藏NIAID Data Ecosystem2026-05-01 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景：
创建时间：
2023-09-08
相关数据集
Source Data
This is the source data from our publication/Murphy, S.A., Miyamoto, M., Kervadec, A. et al. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Nat Commun
DataCite Commons2025-01-30 更新240
AP-1 activation mediates postnatal cardiomyocyte maturation. AP-1 activation mediates postnatal cardiomyocyte maturation
Mammalian cardiomyocytes rapidly mature after birth, with hallmarks such as cell-cycle exit, binucleation, and metabolic switch to oxidative phosphorylation of lipids. The causes and transcriptional p
NIAID Data Ecosystem70
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation and myofibrillar organization
Rationale: The molecular basis of cardiomyocyte (CM) maturation is not fully known. Human pluripotent stem cell-derived CMs (iPSC-CMs) are a valuable tool to reconstruct the CM maturation process and
NIAID Data Ecosystem10
Perlecan (HSPG2) signalling promotes structural, contractile, and metabolic development during the maturation stage of hPSC-CM differentiation. Perlecan (HSPG2) signalling promotes structural, contractile, and metabolic development during the maturation stage of hPSC-CM differentiation
Perlecan (HSPG2), a multifunctional heparan sulphate proteoglycan (HSPG), is a key player in extracellular matrix maturation and stabilisation. Structurally perlecan is similar to agrin, another HSPG
NIAID Data Ecosystem70
AMPK-dependent maturation of hiPSC-derived cardiomyocytes induced by human cardiac fibroblast exosomes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising therapy for ischemic cardiomyopathy, which is often secondary to hypertension but remain functionally immature. W
NIAID Data Ecosystem10
