How DNA sequence affects the dynamics and position of RNA Polymerase II during transcription remains poorly understood. Here we used naturally occurring genetic variation in F1 hybrid mice to explore

NIAID Data Ecosystem40

Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes

RNA聚合酶转录机制

核苷三磷酸扩散路径

The RNA polymerase II (Pol II) is a eukaryotic enzyme that catalyzes the synthesis of the messenger RNA using a DNA template. Despite numerous biochemical and biophysical studies, it remains elusive w

NIAID Data Ecosystem30

DNA breaks at RNA Pol II pausing sites

DNA双链断裂

RNA聚合酶转录机制

DNA double-stranded breaks (DSBs) are strongly associated with active transcription. Using genome-wide DNA break mapping techniques at single-nucleotide resolution, we investigated the DNA DSB distrib

NIAID Data Ecosystem40

Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble

RNA聚合酶转录机制

转录泡结构解析

Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble

NIAID Data Ecosystem40