X-ray crystal structure of wild type HIV-1 protease in complex with GRL-08613
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
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X-ray crystal structure of wild type HIV-1 protease in complex with GRL-08613 Descriptor: (3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl {(2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-[(2-methylpropyl)({2-[(propan-2-yl)amino]-1,3-benzothiazol-6-yl}sulfonyl)amino]butan-2-yl}carbamate, Protease Authors: Yedidi, R.S, Hayashi, H, Ghosh, A.K, Mitsuya, H. Deposit date: 2019-11-05 Release date: 2020-11-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro. Antimicrob.Agents Chemother., 66, 2022
创建时间：
2019-11-05
