Effect of Dietary Lysine Restriction on the Global Gene Expression Profile of Skeletal Muscle in Growing Pigs

Lysine, an essential amino acid (AA) for pig nutrition, is typically the first limiting AA in those common grain-based swine diets. At biochemical level, lysine has regulatory effects on gene expression, which can alter animal metabolic and signaling pathways associated with protein and lipid metabolism.The hypothesis for this study is that the dietary lysine restriction will negatively affect the genes expression associated with muscle protein accretion and lipid metabolism.The objective of this study was to use RNA-Seq to investigate the effects of dietary lysine restriction on the global gene expression profile in the longissimus dorsi muscle of young growing pigs.