Gene expression profiling of CD11c+ or CD11b+ cells from bronchoalveolar lavage fluid was conducted in a bleomycin-induced pulmonary fibrosis model following GW5074 treatment or in Clec7a KO mice.

To investigate the role of the Dectin-1 signaling pathway in the development of pulmonary fibrosis, we established a BLM-induced pulmonary fibrosis model using WT mice, Dectin-1-deficient mice (KO), and GW5074-treated mice. CD11b+ or CD11c+ cells were sorted by flow cytometry and subjected to single-cell RNA sequencing.