Differences in tissue immune cell populations following hematopoietic stem cell transplantation in Crohnâs disease patients
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Treatment of severely refractory Crohnâs disease (CD) patients remains a clinical challenge. Recent studies show the efficacy of autologous hematopoietic stem cell transplant (HSCT) in these severely compromised patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available. We studied a group of CD patients receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanism driving efficacy, we studied changes in the immune cell composition in tissue induced by HSCT.
提供机构：
IDIBAPS
创建时间：
2022-02-20
