The top most synergistic drug pairs based on the TIMMA model predictions in MDA-MB-231 breast cancer cells.

DSS1/2, measured treatment efficacy (drug sensitivity score) when using either of the suggested drugs alone; Inhibition percentage, averaged inhibition of cell growth in the pairwise siRNA screen; Predicted efficacy, predicted treatment efficacy by the TIMMA model; Synergy score, synergistic effect of the drug pair as either measured by the siRNA experiment (Eq. 9) or predicted by the TIMMA model (Eq. 10). The table lists the drug pairs with synergy scores higher than the selected cut-off threshold (0.36, red dotted line in Figure 10B).