Crystal structure of thrombin in complex with compound 14b

Crystal structure of thrombin in complex with compound 14b Descriptor: 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE, Hirudin, thrombin Authors: Tucker, T.J, Brady, S.F, Lumma, W.C, Lewis, S.D, Gardel, S.J, Naylor-Olsen, A.M, Yan, Y, Sisko, J.T, Stauffer, K.J, Lucas, B.Y, Lynch, J.J, Cook, J.J, Stranieri, M.T, Holahan, M.A, Lyle, E.A, Baskin, E.P, Chen, I.-W, Dancheck, K.B, Krueger, J.A, Cooper, C.M, Vacca, J.P. Deposit date: 2004-05-19 Release date: 2004-06-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position J.Med.Chem., 41, 1998凝血酶与化合物14b结合的晶体结构 结合组分描述：1-[2-氨基-2-环己基乙酰基]-吡咯烷-3-羧酸 5-氯-2-(2-乙基氨基甲酰乙氧基)-苯甲酰胺、水蛭素、凝血酶 作者：Tucker, T.J、Brady, S.F、Lumma, W.C、Lewis, S.D、Gardel, S.J、Naylor-Olsen, A.M、Yan, Y、Sisko, J.T、Stauffer, K.J、Lucas, B.Y、Lynch, J.J、Cook, J.J、Stranieri, M.T、Holahan, M.A、Lyle, E.A、Baskin, E.P、Chen, I.-W、Dancheck, K.B、Krueger, J.A、Cooper, C.M、Vacca, J.P 存档日期：2004-05-19 发布日期：2004-06-08 最后修改日期：2024-11-20 实验方法：X射线衍射（分辨率1.9 Å） 引用文献：《设计并合成一系列在P1位使用非碱性基团的强效口服生物可利用非共价凝血酶抑制剂》，《药物化学杂志》，第41卷，1998年