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Rad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress.

Alliance of Genome Resources2026-08-01 收录

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复制叉稳定性调控

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https://www.yeastgenome.org/dataset/GSE68214 数据链接链接失效反馈

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资源简介：

Replication stress activates the Mec1ATR and Rad53 kinases

应用场景：

MYC蛋白修饰

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Mapping Replication Stress-Dependent Transcriptional Events Dependent on ATM or ATMIN by RNA-seq. Mus musculus

DNA复制应激响应

转录组学分析

The cellular response to replication stress requires the DNA-damage responsive kinase ATM and its co-factor ATMIN, however the roles of this signaling pathway following replication stress are unclear.

NIAID Data Ecosystem40

Genome-wide chromatin conformation capture (Hi-C) analysis in fission yeast.. Schizosaccharomyces pombe

三维基因组学

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The dynamic nature of genome organization impacts critical nuclear functions including the regulation of gene expression, replication and DNA damage repair. Despite significant progress, the mechanism

NIAID Data Ecosystem20

Shelterin Mediates Genome Reorganization in Response to Replication Stress (Microarray CGH). Schizosaccharomyces pombe

DNA复制应激响应

三维基因组结构

NIAID Data Ecosystem50

Multimerization of MYC shields stalled replication forks from RNA polymerase [BLISS]. Multimerization of MYC shields stalled replication forks from RNA polymerase [BLISS]

DNA复制应激响应

MYC基因功能

Oncoproteins of the MYC family drive the development of numerous human tumors. In unperturbed cells, MYC proteins bind to virtually all active promoters and control transcription by RNA Polymerase II

NIAID Data Ecosystem30

Rad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress.

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