Resveratrol is a natural polyphenol in lots of foods and traditional Chinese medicines, which has shown promising treatment for neurodegenerative diseases (NDs). However, the molecular mechanisms of i
To determine transcriptome changes in spinal cord induced by the GarsdelETAQ mutation. How mutations in broadly expressed housekeeping genes lead to neurodegeneration in specific cell types remains un
Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent mol
Microglia are critical for brain development and play a central role in Alzheimer's disease (AD) etiology. Down syndrome (DS), also known as trisomy 21, is the most common genetic origin of intellectu
The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid
