New Acylphloroglucinol Derivatives with Diverse Architectures from <i>Hypericum henryi</i>

Hyphenrones
A–F (1–6),
six polycyclic polyprenylated acylphloroglucinol derivatives with
four architectures including three unprecedented cores as exemplified
by 1, 3, and 4, were isolated
from Hypericum henryi. Compounds 3 and 4 possess two unique 5/8/5 and 6/6/5/8/5 fused ring systems,
respectively. Their absolute configurations were defined by experimental
and calculated ECD of 4 and X-ray diffractions of 5 and 6, coupled with their putative biosynthetic
origins. Three compounds exhibited interesting AChE inhibitory activities.