Comparison of expression data from DLD-1 subpopulations I

The function of cell-cell contact for radiochemosensitivity is unclear. Here, we investigate the role of the E-cadherin/catenin complex proteins under more physiological three-dimensional (3D) cell culture conditions in a panel of CRC cell lines. To gain further insights, differential gene expression was investigated in DLD-1 subpopulations showing distinct morphology and invasion in 3D collagen type I. RNA extracted from DLD-1 subpopulations grown in 3D collagen type I (n=3 per subpopulation) was used for Affymetrix microarrays.