Human Endogenous Retrovirus Database

Endogenous retroviruses (ERVs) are common in vertebrate genomes; a typical mammalian genome contains tens to hundreds of thousands of ERV elements. Most ERVs are evolutionarily old and have accumulated multiple mutations, playing important roles in physiology and disease processes. The Human Endogenous Retrovirus Database (hERV) is compiled from the human genome nucleotide sequences obtained from Human Genome Projects, and screens those sequences for hERVs, whilst continuously improving classification and characterization of retroviral families. It provides access to individual reconstructed HERV elements, their sequence, structure and features.

内源性逆转录病毒（ERVs）在脊椎动物基因组中普遍存在；典型的哺乳动物基因组中包含数万至数十万个ERV元件。大多数ERVs在进化过程中形成，并累积了多种突变，在生理和疾病进程中扮演着至关重要的角色。人类内源性逆转录病毒数据库（hERV）由来自人类基因组计划的基因组核苷酸序列汇编而成，对序列进行筛选以识别hERVs，并持续优化逆转录病毒家族的分类和特征描述。该数据库提供了对单个重构的HERV元件、其序列、结构和特性的访问。

搜集汇总

背景与挑战

背景概述

HERVd是一个人类内源性逆转录病毒数据库，收录了脊椎动物基因组中普遍存在的内源性逆转录病毒信息，这些病毒在基因调控、胎盘形成和免疫反应等生理和疾病过程中具有重要作用。数据库提供了相关参考文献和联系人，支持研究人类基因组中的病毒元素。