Additional file 2 of Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics

Additional file 2: Table S1. Detailed participant description (with effect size). Table S2. Average (SD) protein levels for MCI groups of CCC (517 proteins) and EMIF-AD (570 proteins) cohorts and statistical analysis. Table S3. GO Reactome overrepresentation analysis for all 517 and 570 proteins from CCC and EMIF-AD cohorts, respectively, evaluated on this study. Table S4. GO Panther overrepresentation Fisher test for all proteins identified for CCC cohort (517) and evaluated in EMIF-AD cohort (570) with FDR correction. Table S5. Proteins resulting from the PLS-DA multivariate analysis for CCC (164) and EMIF-AD (170) cohorts. Table S6. GO Panther overrepresentation Fisher test for proteins resulting from PLS-DA analysis of CCC (164) and EMIF-AD (170) cohorts with FDR correction. Table S7. nNMF fit criteria on PLS-DA-selected proteins from each cohort. Table S8. Clusters from CCC and EMIF-AD cohorts. Three-cluster solution. Table S9. GO Panther overrepresentation Fisher test for proteins from each cluster from CCC or EMIF-AD cohort with FDR correction. Tree-cluster solution. Table S10. Clusters from CCC and EMIF-AD cohorts. Two-cluster solution. Table S11. GO Panther overrepresentation Fisher test for proteins from each cluster from CCC or EMIF-AD cohort with FDR correction. Table S12. Clinical and demographic comparisons of patients between clusters and cohorts.