Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine

Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine Descriptor: N~6~-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)-4,5'-bipyrimidine-2',6-diamine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION Authors: Knapp, M.S, Elling, R.A, Ornelas, E. Deposit date: 2011-08-24 Release date: 2012-08-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The Identification of 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine (NVP-BKM120) as a Potent, Selective and Orally Bioavailable Class I PI3 Kinase Inhibitor for the Treatment of Cancer To be Published

PI3Kγ（PI3K gamma）与N6-(3,4-二甲氧基苯基)-2-吗啉代-[4,5'-联嘧啶]-2',6-二胺共晶结构
描述项：N6-(3,4-二甲氧基苯基)-2-(4-吗啉基)-4,5'-联嘧啶-2',6-二胺、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型、硫酸根离子
作者：Knapp, M.S.、Elling, R.A.、Ornelas, E.
提交日期：2011-08-24
发布日期：2012-08-29
最后修改日期：2023-09-13
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.7埃（Å）
引用文献：《鉴定5-(2,4-二吗啉代嘧啶-6-基)-4-(三氟甲基)吡啶-2-胺（NVP-BKM120）作为强效、选择性且口服生物可利用的I类PI3激酶抑制剂用于癌症治疗》（待发表）