Curated Spike Protein Sequences from 20 Reference Coronaviruses Across Alpha- and Betacoronavirus Genera

This dataset comprises amino acid sequences of the spike (S) glycoprotein from 20 reference coronaviruses, spanning three taxonomic groups: Sarbecovirus (n=11; e.g., SARS-CoV-1, SARS-CoV-2, RaTG13, BANAL-52, 16BO133), Merbecovirus (n=3; e.g., MERS-CoV, HKU4, HKU5), and Alphacoronavirus (n=6; e.g., HKU2, ZC45, ZXC21). Sequences were derived from NCBI reference genomes, standardized into FASTA format, and organized by subgenus. Accompanying metadata includes accession numbers, host species, genome length, and GC content. This resource supports evolutionary, structural, and functional studies of coronavirus spike diversity. Generated during structural prediction efforts using AlphaFold/ColabFold (October 2025). Data processifn and curation by: [e-mail]