Anti-inflammatory Terpenoids from the Leaves and Twigs of <i>Dysoxylum gotadhora</i>

Nine new terpenoids (1–3, 5–10), including
three cyclolanostane
triterpenoids (1–3) and six isopimarane
diterpenoids (5–10), along with six
known terpenoids (4, 11–15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy
cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type
triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition
of nitric oxide production induced by lipopolysaccharide in RAW 264.7
cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2
μM, respectively.