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Single-cell transcriptomics revealed a critical role of SPP1/CD44-mediated crosstalk between macrophages and cancer cells in glioma

NIAID Data Ecosystem2026-03-13 收录

胶质瘤免疫微环境

肿瘤-免疫细胞互作

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE185231 数据链接链接失效反馈

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资源简介：

a single-cell RNA sequencing analysis of one high-grade glioma with wide-type IDH genes, revealing the landscape of tumor and immune cells in the ecosystem of this tumor one sample from glioma tissue

应用场景：

创建时间：

2022-01-30

胶质瘤免疫微环境

肿瘤预后标志物

Patients diagnosed with glioblastomas continue to have a dismal prognosis, highlighting the need for a better characterization of these tumors in order to identify more efficient therapies. In this st

NIAID Data Ecosystem100

Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression. Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression

胶质瘤免疫微环境

性别二态性免疫反应

Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-seq) used to dissect myeloid cell identities and states in murine experimental gliomas (GL261). Overall design: CITE-seq sequencing

NIAID Data Ecosystem60

MOESM7 of EGFR mutation: novel prognostic factor associated with immune infiltration in lower-grade glioma; an exploratory study

胶质瘤免疫微环境

EGFR突变

Additional file 7: Figure S2. Cytokine Profiling heat maps. Chemokines, lymphokines and phenotype markers of macrophages estimations of EGFR-MUT and EGFR-WT cases were revealed using heat maps.

Figshare2019-12-04 更新30

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

胶质瘤免疫微环境

肿瘤预后生物标志物

Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined. Moreover, the ch

NIAID Data Ecosystem100

Data_Sheet_11_CD44-Mediated Poor Prognosis in Glioma Is Associated With M2-Polarization of Tumor-Associated Macrophages and Immunosuppression.PDF

胶质瘤免疫微环境

肿瘤相关巨噬细胞M2极化

BackgroundGlioma is the most common primary brain tumor with a poor prognosis. Key genes that are negatively related to prognosis may provide the therapy targets to cure glioma. To clarify the role of

NIAID Data Ecosystem40

Single-cell transcriptomics revealed a critical role of SPP1/CD44-mediated crosstalk between macrophages and cancer cells in glioma

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