Additional file 5: of Tumor mutational burden quantification from targeted gene panels: major advancements and challenges

Table S5. Empirical analysis of TMB association or predictive value for immunotherapy response. These analyses were performed on panel-based TMB values, directly calculated by panel sequencing. The table reports measures of TMB association with immunotherapy response (odds ratios, hazard ratios and corresponding p-values), differences in TMB distribution between responders and non-responders (Mann-Whitney U, unpaired Student’s t and Fisher’s test p values) and measures of TMB predictive value (AUC, specificity, sensitivity). We also specify how patients were stratified (“Comparison”), the method used to determine TMB cutoff, the cohort considered for the analysis (if different cohorts were analyzed in the study), the type of immunotherapy, cancer type and number of patients. (XLSX 19 kb)