Background The colonic mucus layer plays a critical role in intestinal homeostasis by limiting contact between luminal bacteria and the mucosal immune system. A defective mucus barrier in animal model

NIAID Data Ecosystem120

biopsy_spatial_CosMx.h5ad

RNA原位杂交

溃疡性结肠炎

CosMx 960-plex RNA-ISH dataset of formalin-fixed, paraffin-embedded (FFPE) colon biopsies from healthy controls and patients with ulcerative colitis on aminosalicylates or vedolizumab.

DataCite Commons2024-08-29 更新70

Additional file 6 of Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC

DNA甲基化

溃疡性结肠炎

Additional file 6. List of UC-specific epithelial DNA methylation signatures at diagnosis associated with disease severity defined by PUCAI.

DataCite Commons2023-04-13 更新150

Diversity of intestinal flora in colon tissue

消化道微生物组

溃疡性结肠炎

Lactobacillus acidophilus and HKL suspension alleviates ulcerative colitis in rats via regulating gut microbiota

NIAID Data Ecosystem80