Additional file 2 of Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Additional file 2: Supplemental Table S6. KEGG enrichment of variant genes that can be linked to genome instability. Supplemental Table S7. Statistically significant Biological Process GO terms of variant genes. Supplemental Table S8. Statistically significant Molecular Function GO terms of variant genes. Supplemental Table S9. Statistically significant Cellular Component GO terms of variant genes. Supplemental Table S10. Complete list of microsatelites found in the Chinese hamster genome. Supplemental Table S11. Microsatellites containing insertion and or deletion mutations. Supplemental Table S12. Indel loci with higher mutation frequencies in 30 mM ammonia-stressed cultures. Supplemental Table S13. Indel loci from table S12 where mutation frequency is higher in the 10 mM samples compared to the control. Supplemental Table S14. The intersection of dose-dependent indels (Table S13) and genome-wide microsatellites (S10). Supplemental Table S15. The 124 candidate microsatelite loci that exhibited dose-dependent variation in response to ammonia stress.

附加文件 2：与基因组不稳定性相关联的变异基因的 KEGG 富集补充表 S6。补充表 S7：变异基因的统计学显著生物学过程 GO 术语。补充表 S8：变异基因的统计学显著分子功能 GO 术语。补充表 S9：变异基因的统计学显著细胞组分 GO 术语。补充表 S10：在中国仓鼠基因组中发现的完整微卫星列表。补充表 S11：包含插入和/或缺失突变的微卫星。补充表 S12：在 30 mM 氨胁迫培养中突变频率较高的 Indel 位点。补充表 S13：来自表 S12 的 Indel 位点，其中在 10 mM 样品中的突变频率高于对照组。补充表 S14：剂量依赖性 Indel（表 S13）与全基因组微卫星（S10）的交集。补充表 S15：在氨胁迫响应中表现出剂量依赖性变异的 124 个候选微卫星位点。