Cancer mutations perturb key processes, leading to uncontrolled cell proliferation. With the pivotal and specific roles for enzymes at all levels of cellular function and growth, we hypothesized that

DataONE2025-12-19 更新50

Cohesin maintains replication timing to suppress DNA damage on cancer genes [MCM5_ChIPseq]

DNA复制应激

基因组不稳定性

Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism is unclear. Here, we found that depletion of RAD21, a core subunit of cohesin, leads to massive genome-wide DNA

NIAID Data Ecosystem30

Gene expression of fibroblasts carrying SAMHD1 mutations or not

基因表达分析

基因组不稳定性

In mammalian cells, the catabolic activity of the dNTP triphosphohydrolase SAMHD1 sets the balance and the concentrations of the four dNTPs. Deficiency of SAMHD1 leads to unequally increased pools and

NIAID Data Ecosystem50

Loss of histone demethylase JARID1C triggers genomic instability in cancer.

癌细胞调控

基因组不稳定性

Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the gene

NIAID Data Ecosystem40

Distribution of samples according to the level of genomic instability.

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