Histidine catabolism

The major pathway of histidine catabolism, annotated here, proceeds in four steps to yield glutamate and, in the process, convert one molecule of tetrahydrofolate to 5-formiminotetrahydrofolate (Morris et al. 1972). Histidine can also be decarboxylated to form histamine. Histidine can also be used to form carnosine (beta-alanyl-L-histidine), an abundant dipeptide in skeletal muscle and brain of most vertebrates.

本数据集标注了组氨酸降解途径的主要途径，该途径分为四个步骤，最终生成谷氨酸，并在过程中将一分子四氢叶酸转化为5-甲酰基四氢叶酸（Morris 等，1972年）。组氨酸还可以通过脱羧反应生成组胺。此外，组氨酸还可用于合成卡尼丁（β-丙氨酰-L-组氨酸），这是大多数脊椎动物骨骼肌和大脑中含量丰富的二肽。