Daphnane diterpenoids as potent and tolerable importin-b1 inhibitors to treat castration-resistant prostate cancer

NIAID Data Ecosystem2026-03-13 收录

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importin-b1抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179317 数据链接链接失效反馈

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创建时间：

2022-09-03

Systematic characterization of epigenetic modifying enzymes identifies KDM3B as a key regulator in castration resistant prostate cancer. Systematic characterization of epigenetic modifying enzymes identifies KDM3B as a key regulator in castration resistant prostate cancer

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表观遗传靶点

Androgen deprivation therapy (ADT) is the standard care for prostate cancer patients who fail surgery and radiotherapy. While initially effective, the cancer almost always recurs into a more aggressiv

NIAID Data Ecosystem100

Phenotypic characterization of two novel cell line models of castration resistant prostate cancer

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癌症耐药机制研究

Purpose: Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new pre-clinical models that allow the investiga

NIAID Data Ecosystem50

Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)

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OPRK1基因功能

Through comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistanc

NIAID Data Ecosystem30

Identification of the GATA2 transcriptome in the AR-V positive castrate-resistant prostate cancer cell line CWR22Rv1

GATA2

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To interrogate the extent of overlap between GATA2 and AR-V regulated transcriptomes in castrate-resistant prostate cancer cells, we assessed global gene expression changes in GATA2-depleted CWR22Rv1

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ARv7 represses tumor suppressors genes in castration-resistant prostate cancer [RNA-Seq]

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转录抑制机制

Endocrine therapies in prostate cancer (PCa) treatment block androgen receptor (AR) function, but are palliative as tumors progress to a lethal, castration-resistant state (CRPC). CRPC remains depende

NIAID Data Ecosystem50

Daphnane diterpenoids as potent and tolerable importin-b1 inhibitors to treat castration-resistant prostate cancer

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