Summary of E-Flux predicted mycolic acid inhibitors from Boshoff data set.

Results are shown for all significant predictions from the set of 437 experiments in Boshoff et al [17]. Of the seven known inhibitors of fatty acid biosynthesis, E-Flux correctly predicts 6. Strong effects are defined as effects showing greater than +/−3 log change between control and drug; weak inhibitory effects have inhibition less than −1.5 log change and very weak effects less than −1. Weak enhancing effects have greater than +1 log change. Specific effects indicate effects on mycolic acid biosynthesis as contrasted to effects over a broad range of pathways – see text for more details. *Prediction made only for certain replicates. ‡Prediction made only for certain doses. Starvation conditions were phosphate- or Tris-buffered saline containing 0.05% Tween 80 (PBST or TBST) [17]. Conditions with both enhancing and inhibiting predictions among replicates were excluded.