Transcriptome changes in Huntington's disease with SUMO-1 depletion

NIAID Data Ecosystem2026-03-12 收录

亨廷顿病转录组

SUMO化修饰

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https://www.ncbi.nlm.nih.gov/sra/SRP315420 数据链接链接失效反馈

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NOT PROVIDED; REQUESTED Overall design: Mouse brain striatal total RNA-seq of WT, HD, SUMO-1 KO in HD, and SUMO-1 KO in WT mouse

创建时间：

2021-04-21

A new chemical and enzymatic approach to analyze protein sumoylation site.

SUMO化修饰

翻译后修饰

(A) Schematic of the conventional method using intact SUMO remnant as a signature for MS analysis. (B) Schematic of our new method (see text for details). (C) In vitro sumoylation reaction was perform

NIAID Data Ecosystem50

SUMO modification of LBD30 by SIZ1 regulates secondary cell wall formation in Arabidopsis thaliana

次生细胞壁发育

SUMO化修饰

A wide range of biological processes are regulated by sumoylation, a post-translational modification involving the conjugation of SUMO (Small Ubiquitin-Like Modifier) to protein. In Arabidopsis thalia

NIAID Data Ecosystem30

Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM)

蛋白质结构生物学

SUMO化修饰

Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) Descriptor: Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1 Authors: Song, J, Zhang, Z, Hu, W, Chen, Y.

Protein Data Bank Japan2024-05-22 更新20

Targeting UBC9-mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models

多囊肝病机制

SUMO化修饰

Background & Aims: polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in prote

NIAID Data Ecosystem30

Effects of sumoylation-impairing mutation of TFIIF subunit Tfg1 on genome-wide RNA polymerase II (RNAPII) levels in budding yeast

转录调控

SUMO化修饰

Many transcription-related proteins, including components of the RNA polymerase II (RNAPII) general transcription factors (GTFs), have been shown through proteomics studies to be modifiable by SUMO co

NIAID Data Ecosystem30

Transcriptome changes in Huntington's disease with SUMO-1 depletion

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