Code from: Sensory feedback and central neuronal interactions in mouse locomotion

Locomotion is a complex process involving specific interactions between the central neural controller and the mechanical components of the system. The basic rhythmic activity generated by locomotor circuits in the spinal cord defines rhythmic limb movements and their central coordination. The operation of these circuits is modulated by sensory feedback from the limbs providing information about the state of the limbs and the body. However, the specific role and contribution of central interactions and sensory feedback in the control of locomotor gait and posture remain poorly understood. We use biomechanical data on quadrupedal locomotion in mice and recent findings on the organization of neural interactions within the spinal locomotor circuitry to create a tractable mathematical model of mouse locomotion. The model includes feedback signals characterizing the load and extension of each limb as well as postural stability. We investigate several model versions and compare their behavior ..., , , # Mouse locomotion model — simulation code Source code and run scripts accompanying: > Molkov YI, Yu G, Ausborn J, Bouvier J, Danner SM, Rybak IA. **Sensory feedback and central neuronal interactions in mouse locomotion.** *Royal Society Open Science* 11(8): 240207 (2024). [doi:10.1098/rsos.240207](https://doi.org/10.1098/rsos.240207) The paper develops a tractable mathematical model of quadrupedal mouse locomotion that combines biomechanics with the spinal locomotor circuitry, and uses it to dissect the contributions of sensory feedback and central neuronal interactions to gait and posture across speeds. ## Repository layout The bundle is distributed as `code.zip`. Unzip it to get three self-contained model variants, each in its own directory: ``` code.zip └── code/ ├── model1/ ├── model2/ └── model3/ ``` | Directory | Variant ..., ,