Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor Descriptor: 5-azanyl-3-[1-[[(2~{R})-1-methylpiperidin-2-yl]methyl]indol-6-yl]-1~{H}-pyrazole-4-carbonitrile, tRNA (guanine-N(1)-)-methyltransferase Authors: Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L. Deposit date: 2019-02-19 Release date: 2019-09-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches. J.Med.Chem., 62, 2019

脓肿分枝杆菌（Mycobacterium abscessus）来源的TrmD——一种tRNA-(N1G37)甲基转移酶（tRNA-(N1G37) methyltransferase），与抑制剂结合的晶体结构。抑制剂标识符：5-氨基-3-[1-[[(2R)-1-甲基哌啶-2-基]甲基]吲哚-6-基]-1H-吡唑-4-甲腈。该酶同时为tRNA(鸟嘌呤-N(1)-)甲基转移酶。作者：Thomas, S.E、Whitehouse, A.J、Coyne, A.G、Abell, C、Mendes, V、Blundell, T.L。沉积日期：2019-02-19；发布日期：2019-09-18；最后修改日期：2024-01-24。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.52埃。引用文献：《基于片段筛选策略开发抗脓肿分枝杆菌tRNA(m1G37)甲基转移酶（TrmD）抑制剂》（Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches），《J.Med.Chem.》，2019年，第62卷。