Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir
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Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease Authors: Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. Deposit date: 2013-11-11 Release date: 2014-04-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014
创建时间：
2013-11-11
