Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir

Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with darunavir Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease Authors: Yedidi, R.S, Garimella, H, Chang, S.B, Kaufman, J.D, Das, D, Wingfield, P.T, Ghosh, A.K, Mitsuya, H. Deposit date: 2013-11-11 Release date: 2014-04-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. Antimicrob.Agents Chemother., 58, 2014耐多药临床分离株A02的人类免疫缺陷病毒1型（HIV-1）蛋白酶与达芦那韦（darunavir）复合物的晶体结构 配体描述符：(3R,3AS,6AR)-六氢呋喃并[2,3-B]呋喃-3-基(1S,2R)-3-[[(4-氨基苯基)磺酰基](异丁基)氨基]-1-苄基-2-羟基丙基氨基甲酸酯 蛋白酶 作者：Yedidi, R.S.、Garimella, H.、Chang, S.B.、Kaufman, J.D.、Das, D.、Wingfield, P.T.、Ghosh, A.K.、Mitsuya, H. 存储日期：2013-11-11 发布日期：2014-04-02 最后修改日期：2024-02-28 实验方法：X射线衍射（分辨率1.95埃） 引用文献：含P2双四氢呋喃结构的HIV-1蛋白酶抑制剂（PIs）与蛋白酶活性位点氨基酸骨架的保守氢键网络可增强其对抗蛋白酶抑制剂耐药HIV的活性。《抗菌剂与化疗》（Antimicrob. Agents Chemother.），58卷，2014年