T cell characterization

To characterize ex vivo CD4 andCD8 T lymphocytes Conclusion: Studies on chemokine receptors and lineage-specifying transcription factors revealed that, among CD4+ T cells, patients displayed a lower percentage of cells expressing CCR6 or CXCR3, and of those co-expressing CCR6 and CD161, but higher percentages of CXCR4+ or CCR4+ cells. No differences were noted in the expression of T-bet or GATA-3. CD8+ T cells expressed lower percentages of CCR6+, CXCR3+ or T-bet+ cells and of CXCR3+,T-bet+ or CCR6+,CD161+ lymphocytes. We also found higher percentages of cells expressing CCR4+, CXCR4 or GATA-3. Notes: We provide an in-depth investigation of the T cell compartment in a total of 39 patients affected by Covid-19 pneumonia. T cell phenotype