Cyclic di-GMP Suppresses Cancer Metastasis by Targeting PSMD3 independently of STING

To elucidate the molecular mechanism(s) underlying c-di-GMP-mediated metastasis inhibition, we performed RNA sequencing (RNA-seq) analysis in MDA-MB-231 cells treated with 5 uM of c-di-GMP for 24 hours. Overall design: Comparative gene expression profiling analysis of RNA-seq data for MDA-MB-231 breast cancer cells from c-di-GMP treated and non-treated groups.