Novel IDH1 Mutant Inhibitors for Treatment of Acute Myeloid Leukemia
收藏NIAID Data Ecosystem2026-03-08 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
应用场景：
创建时间：
2015-08-20
相关数据集
Expression data from MOLM-14 human acute myeloid leukemia cell line after AMPK activation by GSK621 according to mTORC1 activation level
AMPK activation by GSK621 induces cell death in acute myeloid leukemia. Surprisingly, we found that mTORC1 inhibition with rapamycin protects cells against GSK621-induced cytotoxicity. A genome-wide g
NIAID Data Ecosystem50
Immune-related gene expression data of whole blood and spleen from immuno-competent mice implanted with C1498 leukemia cells (AML model) and treated with 5-Azacytidine or Vehicle
Significant differences in gene expression were observed for 5-Azacytidine treated leukemic mice compared to vehicle treated mice during hematologic remission in both spleen and blood samples C57Bl/6
NIAID Data Ecosystem20
datasheet2_Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells.pdf
Acute myeloid leukemia (AML) is an aggressive haematological malignancy characterized by highly proliferative accumulation of immature and dysfunctional myeloid cells. Quercetin (Qu), one kind of flav
NIAID Data Ecosystem10
Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia
Nowadays, the simultaneous inhibition of two or more pathways plays an increasingly important role in cancer treatment due to the complex and diverse pathogenesis of cancer, and the combination of the
NIAID Data Ecosystem30
Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2‑Thiohydantoin Compounds
Somatic mutations of isocitrate dehydrogenase 1 (IDH1) at R132 are frequently found in certain cancers such as glioma. With losing the activity of wild-type IDH1, the R132H and R132C mutant proteins c
NIAID Data Ecosystem20
