Analyses of HLA class I variants previously or presently associated with acquisition or control of HIV-1 infection.

Analyses are based on 240 seroconverters (SCs) and 328 the persistent HIV-1 exposed seronegatives (pHESNs). Group I HLA variants include those associated with time to HIV-1 acquisition in both univariate and multivariable models (Table 3). Group II has variants that are rejected by multivariable models (adjusted p>0.050). Other variants under Group III have been highlighted in earlier studies relevant to heterosexual HIV-1 acquisition and/or immune control of infection. Variants highly relevant to Zambians are underlined. Age and gender are treated as covariates in all analyses. The q values correspond to false discovery rates.