Differential equations of the G2-M model.

The parameters of the ODEs are: ks is the rate of CycB synthesis and is associated with the concentration of Cdk1; kd describes the degradation rate of CycB and the degradation rates of MPF. V25 and Vwee are the activation and inactivation rates of MPF, respectively. Kawee and Kiwee are the rates of Wee1 being activated by a phosphatase (which is not explicitly formulated in our model) and inactivated by MPF, respectively. Ka25 and Ki25 are the rates of Cdc25 being activated by MPF and inactivated by a phosphatase, respectively. Ja25 and Jiwee are the Michaelis constants of MPF for Cdc25 and Wee1, and Ji25 and Jawee are the Michaelis constants of a phosphatase for Cdc25 and Wee1, respectively.