Sustainability in inhaled drug delivery for global health

The overwhelming majority of maternal deaths occur in the world’s poorest countries. Severe haemorrhaging post-childbirth is the most common cause of maternal death but is preventable with an injection of oxytocin. However, barriers exist to the use of oxytocin in these low-resource health settings, and there is substantial unmet need for more accessible medicines that are cost-effective, high-quality and easy-to-use. An inhalable form of oxytocin presents an opportunity to reduce maternal mortality if it can be sustainably developed, manufactured and implemented. This thesis explores new methods to improve the sustainability of inhaled oxytocin by addressing affordability, useability and quality of inhaled drug delivery for global health applications.