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D-mannose Attenuates Bone Loss in Senile and Ovariectomized Mice via Treg Cell-Induced Anti-inflammatory Effects

NIAID Data Ecosystem2026-03-11 收录

骨丢失机制

免疫调节抗炎

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA564435 数据链接链接失效反馈

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D-mannose Attenuates Bone Loss in Senile and Ovariectomized Mice via Treg Cell-Induced Anti-inflammatory Effects

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创建时间：

2019-09-08

根尖周炎免疫调节

骨丢失机制

V-domain Ig suppressor of T cell activation (VISTA) is a novel coinhibitory immune checkpoint molecule that maintains immune homeostasis. The present study explored the role of VISTA in human and muri

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Bone marrow adipocyte (BMAd)-specific deletion of Pnpla2 reveals local roles for lipolysis to fuel cells of bone and the marrow niche

骨髓脂肪组织代谢

骨丢失机制

Purpose: To determine mechanisms by which BMAd-Pnpla2 deficiency-causes bone loss in calorie restricted (CR) mice, we profiled global gene expression in bone marrow plugs from distal tibiae, a locatio

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IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells

骨丢失机制

类风湿关节炎免疫病理

IL-7, a powerful lymphopoietic cytokine, is elevated in rheumatoid arthritis (RA) and known to induce bone loss when administered in vivo. IL-7 has been suggested to induce bone loss, in part, by stim

PubMed Central2002-12-18 更新00

Fetuin A is an immunomodulator and therapeutic target for Heterotopic ossification and associated bone loss

异位骨化转录组

骨丢失机制

Heterotopic ossification (HO), the pathologic growth of extra-skeletal bone, occurs as a common complication of trauma or in genetic disorders and can be disabling and lethal.We report that mice harbo

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Differential gene expression profiles of long bones of telomerase deficient mice (G3-mTERC-/-)

骨丢失机制

干细胞衰老

Telomere shortening due to telomerase deficiency leads to accelerated senescence of human skeletal (mesenchymal) stem cells (MSC) in vitro. In order to study the role of telomere shortening in vivo, w

Alliance of Genome Resources00

D-mannose Attenuates Bone Loss in Senile and Ovariectomized Mice via Treg Cell-Induced Anti-inflammatory Effects

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