Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]

Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide] Descriptor: 4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK Authors: Han, S, Caspers, N.L. Deposit date: 2013-08-02 Release date: 2014-04-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors. Biochem.J., 460, 2014与化合物7 [4-(氨基甲酰氨基)-1-(7-乙氧基萘-1-基)-1H-吡唑-3-甲酰胺]结合的ITK晶体结构 描述物：4-(氨基甲酰氨基)-1-(7-乙氧基萘-1-基)-1H-吡唑-3-甲酰胺、酪氨酸蛋白激酶ITK/TSK（Tyrosine-protein kinase ITK/TSK） 作者：Han, S.、Caspers, N.L. 提交日期：2013-08-02 发布日期：2014-04-02 末次修改日期：2024-02-28 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15埃（Å） 引用文献：《通过变构抑制剂选择性靶向白细胞介素-2诱导性T细胞激酶的非活性构象》，《生物化学期刊（Biochem.J.）》，第460卷，2014年