ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38)

Protein Data Bank Japan2023-10-11 更新2026-03-21 收录

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ATAD2B bromodomain in complex with 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione (compound 38) Descriptor: 4-({[(3R,4R)-4-{[3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl]amino}piperidin-3-yl]oxy}methyl)-1lambda~6~-thiane-1,1-dione, ATPase family AAA domain-containing protein 2B, SULFATE ION Authors: Glass, K.C. Deposit date: 2020-01-02 Release date: 2020-10-28 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain. J.Med.Chem., 63, 2020

与4-({[(3R,4R)-4-{[3-甲基-5-(5-甲基吡啶-3-基)-2-氧代-1,2-二氢-1,7-萘啶-8-基]氨基}哌啶-3-基]氧基}甲基)-1λ⁶-噻烷-1,1-二酮（化合物38）结合的ATAD2B溴结构域（bromodomain）描述符：4-({[(3R,4R)-4-{[3-甲基-5-(5-甲基吡啶-3-基)-2-氧代-1,2-二氢-1,7-萘啶-8-基]氨基}哌啶-3-基]氧基}甲基)-1λ⁶-噻烷-1,1-二酮、ATP酶家族AAA结构域包含蛋白2B、硫酸根离子作者：Glass, K.C. 存放日期：2020-01-02 发布日期：2020-10-28 最后修改日期：2023-10-11 实验方法：X射线衍射（分辨率2.4 Å）引用文献：《ATAD2B溴结构域识别单乙酰化与二乙酰化组蛋白的结构洞察》，《药物化学杂志》，第63卷，2020年

创建时间：

2020-01-02