Epigenetic-based regulation of transcriptome in Escherichia coli adaptive antibiotic resistance. Epigenetic-based regulation of transcriptome in Escherichia coli adaptive antibiotic resistance

To investigate the transcriptome and global methylation patterns of cytosines and adenines in cells selected for adaptive resistance to ampicillin, gentamicin, and ciprofloxacin Overall design: Comparative gene expression levels evaluated by RNA-sequencing in Escherichia coli JM109 cells (control) and in ampicillin-, gentamicin-, and ciprofloxain resistant cells selected at sub-MIC concentrations and subsequent growth at increasing concentrations of the three antibotics