Over-representation and pathway topology analysis using KEGG pathways terms.

The analysis is based on the molecular elements that constitute the interactome of CAD. Topology analysis is based on degree centrality, which measures the number of links that connects to a node within a pathway. Regulation trend (Trend) is based on differential expression of either *compounds, or **gene\proteins, or ***both. Down-regulation (↓), up-regulation (↑), contradictory regulation or not applicable (NA). General pathway association (class): fatty acids (FA), amino acids (AA), aminoacylation of transfer RNAs (AAcylation), signalling (SIG), energy metabolism (EMET), vitamin 5 as precursor (Vit5), disease (DIS), immune system (IMM), antioxidants (AntiOx), hormonal (HOR), and cytoskeleton (Cytosk). Gene-centric or metabolite-centric analysis (|).