Supplementary Material for: Global trends and hotspots in the association between chronic kidney disease and cardiovascular diseases: a bibliometric analysis from 2010 to 2023

Introduction
This study endeavors to evaluate the distribution patterns and research frontiers within the international literature on the association between chronic kidney disease and cardiovascular diseases in the medical field, through bibliometric analysis and visualized information.

Methods
The Web of Science Core Collection database was selected as the data source from 2010 to 2023, and articles related to the association between chronic kidney disease and cardiovascular diseases were retrieved. The article data was analyzed through CiteSpace for bibliometric mapping, involving the examination of keywords, references, country/region distributions, and institutional contributions to identify and understand the evolving research dynamics and frontiers in this interdisciplinary field.

Results
A total of 2936 publications on the association between chronic kidney disease and cardiovascular diseases were included. The country with the most publications was USA (n=904), and the institution with the most publications was University of Pennsylvania (n=116). The most frequent keywords were chronic kidney disease (n=2194), cardiovascular disease (n=1188), and mortality (n=604). The top 20 keywords and top ten references that burst during 2010 to 2023 were listed.

Conclusion
The association between chronic kidney disease and cardiovascular diseases has sparked extensive research, particularly in high-prevalence areas. From 2010 to 2023, publications on the association between chronic kidney disease and cardiovascular diseases show a linear increase. Current research hotspots and frontiers are mainly in cardiovascular-kidney-metabolic syndrome; innovative therapies and drug impact; gut microbiome; mendelian randomization analysis. Overall, our study offers a comprehensive scientometric analysis of the association between chronic kidney disease and cardiovascular diseases, providing valuable insights for both researchers and healthcare professionals in the field.

引言
本研究旨在通过文献计量分析和可视化信息，评估国际医学领域关于慢性肾脏病与心血管疾病之间关联的研究分布模式和前沿动态。

方法
本研究选取了2010年至2023年的Web of Science核心合集数据库作为数据来源，检索了与慢性肾脏病与心血管疾病之间关联的相关文献。通过CiteSpace进行文献计量映射分析，对关键词、参考文献、国家/地区分布以及机构贡献进行考察，以识别和理解该跨学科领域的演变研究动态和前沿。

结果
共纳入了2936篇关于慢性肾脏病与心血管疾病之间关联的出版物。发表数量最多的国家为美国（n=904），发表数量最多的机构为宾夕法尼亚大学（n=116）。出现频率最高的关键词为慢性肾脏病（n=2194）、心血管疾病（n=1188）和死亡率（n=604）。列出了2010年至2023年间爆发的最频繁的20个关键词和前10个参考文献。

结论
慢性肾脏病与心血管疾病之间的关联引发了广泛的研究，尤其是在高发病率地区。从2010年至2023年，关于慢性肾脏病与心血管疾病之间关联的出版物呈现线性增长。当前的研究热点和前沿主要集中在心血管-肾脏-代谢综合征；创新疗法和药物影响；肠道菌群；孟德尔随机化分析。总体而言，本研究为慢性肾脏病与心血管疾病之间的关联提供了全面的科学计量分析，为该领域的研究人员和医疗保健专业人员提供了宝贵的见解。