p-STAT4 dissociates from IL12RB2:IL12RB2 receptor

Interleukin-35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 4-alpha/beta (STAT4) binds to the JAK associated-IL35 receptor complex and are activated via phosphorylations. Subsequently, phosphorylated p-STAT4 dissociates from the receptor complex (Collison et al. 2012). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT4 from the receptor complex.

白细胞介素-35（IL35）可通过IL35受体介导信号传递，激活下游的JAK/STAT通路。信号转导和转录激活因子4-α/β（STAT4）与JAK相关联的IL35受体复合物结合，并通过磷酸化作用被激活。随后，磷酸化的p-STAT4从受体复合物中解离（Collison等，2012年）。这是一个黑箱事件，因为目前尚无文献证据关于STAT4从受体复合物释放的确切机制。