Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358)

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358) Descriptor: 1,2-ETHANEDIOL, Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE Authors: Kudlinzki, D, Linhard, V.L, Gande, S.L, Sreeramulu, S, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. Deposit date: 2016-02-21 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem. Biol., 11, 2016达努塞替（danusertib，代号PHA739358）结合艾法林A2（Ephrin A2，即EphA2）受体蛋白激酶的晶体结构 描述符：1,2-乙二醇（1,2-ETHANEDIOL）、艾法林A型受体2（Ephrin type-A receptor 2）、N-[(3E)-5-[(2R)-2-甲氧基-2-苯乙酰基]吡咯并[3,4-c]吡唑-3(5H)-亚基]-4-(4-甲基哌嗪-1-基)苯甲酰胺 作者：Kudlinzki, D, Linhard, V.L, Gande, S.L, Sreeramulu, S, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H 提交日期：2016-02-21 发布日期：2016-11-09 最后修改日期：2024-01-10 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.698 Å） 引用文献：《化学蛋白质组学与结构生物学阐明临床激酶药物对EPHA2的抑制作用》，ACS Chem. Biol., 11, 2016