A Peptide Immunomodulator Potentiates Regulatory T Cells via MST1 Kinase Activation to Promote Immune Tolerance in Mice and Humanized Models

DLST-6P is an-AI designed oligipeptide that can activate Tregs to drive robust immune tolerance for treating various autoimmune and inflammatory diseases. It can not only preferentially amplify IL-2 signaling in tregs without overactive other immune cells, but also stablized Tregs against inflammatory niche.