Regio‑, Diastereo‑, and Enantioselective Nitroso-Diels–Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids
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https://figshare.com/articles/dataset/Regio_Diastereo_and_Enantioselective_Nitroso_Diels_Alder_Reaction_of_1_3_Diene_1_carbamates_Catalyzed_by_Chiral_Phosphoric_Acids/2128849
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资源简介：
Chiral phosphoric acid-catalyzed
asymmetric nitroso-Diels–Alder
reaction of nitrosoarenes with carbamate-dienes afforded cis-3,6-disubstituted dihydro-1,2-oxazines in high yields with excellent
regio-, diastereo-, and enantioselectivities. Interestingly, we observed
that the catalyst is able not only to control the enantioselectivity
but also to reverse the regioselectivity of the noncatalyzed nitroso-Diels–Alder
reaction. The regiochemistry reversal and asynchronous concerted mechanism
were confirmed by DFT calculations.
创建时间：
2016-02-13
