Zonarol suppresses the expression of pro-inflammatory signaling molecules, such as iNOS, in mice with DSS-induced UC. A, B

) IHC of iNOS showed that, in established DSS-induced UC, the iNOS expression level (i.e., the iNOS-positive area) was substantially upregulated, especially in the surface colonic epithelium of the DSS positive control mice, but not in the mice treated with zonarol, on day 15 post-DSS administration (n = 6 mice per group). No apparent iNOS-positive areas were seen in the sham-treated normal control mice. Scale bar = 100 µm. The values are the means ± SE. *P